17/02/2016, 16:40
6.
Jernej Rus (Abelium, FMF) - Strong traces as a model for self-assembly polypeptide nanostructures
17/02/2016, 17:00
In 2011 Gradišar et al. presented a novel self-assembly strategy for polypeptide nanostructure design that could lead to significant developments in biotechnology. We will talk about strong traces (closed walk which traverse every edge exactly twice and for every vertex $v$, there is no subset $N$ of its neighbors, with $1 \leq |N| < d(v)$, such that every time the walk enters $v$ from $N$, it...
Igor Drobnak
(National Institute of Chemistry, Slovenia)
The design of novel proteins to efficiently carry out specific tasks is one of the major long-term goals in biomolecular research. This task is made extremely difficult by the large number of degrees of freedom in protein structures and by the large number of competing interactions that contribute to protein stability. Recent work by our group has demonstrated that the problem can be made more...
Jana Aupic
(National Institute of Chemistry)
One of the approaches to designing new protein folds relies on using modular building blocks, e.g. coiled-coils that interact only with their cognate pair in a well-understood fashion. A recent result of this kind of design strategy is a tetrahedron constructed from a single polypeptide chain composed of six pairs of coiled-coil forming segments[1]. The order of segments in a protein sequence...
